V89M (p.Val89Met) variant of SOST (Sclerostin)
V89M (p.Val89Met) in SOST (Sclerostin) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes population frequency data and structural context.
V89M (p.Val89Met) variant details
- p.Val89Met
- rs867579353
- TOPMed rs867579353
- gnomAD rs867579353
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.542
- REVEL 0.54
- CADD 25.20
- PolyPhen-2 0.66
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available