V75M (p.Val75Met) variant of SOST (Sclerostin)
V75M (p.Val75Met) in SOST (Sclerostin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
V75M (p.Val75Met) variant details
- p.Val75Met
- ExAC rs774141032
- TOPMed rs774141032
- gnomAD rs774141032
- Missense
- Variant Prioritization Score for Impact Estimate 0.209
- REVEL 0.11
- CADD 13.10
- PolyPhen-2 0.00
- SIFT 0.23
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available