R87H (p.Arg87His) variant of SOST (Sclerostin)
R87H (p.Arg87His) in SOST (Sclerostin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
R87H (p.Arg87His) variant details
- p.Arg87His
- TOPMed rs1974123446
- Missense
- Variant Prioritization Score for Impact Estimate 0.438
- REVEL 0.38
- CADD 24.40
- PolyPhen-2 0.02
- SIFT 0.03
- Most common in the Middle Eastern population (allele frequency 0.00018)
- Structural context available