R81C (p.Arg81Cys) variant of SOST (Sclerostin)
R81C (p.Arg81Cys) in SOST (Sclerostin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
R81C (p.Arg81Cys) variant details
- p.Arg81Cys
- gnomAD rs1248654294
- Missense
- Variant Prioritization Score for Impact Estimate 0.61
- REVEL 0.58
- CADD 26.10
- PolyPhen-2 0.06
- SIFT 0.00
- Most common in the Finnish in Finland (FIN) population (allele frequency 2.7e-05)
- Structural context available