R58Q (p.Arg58Gln) variant of SOST (Sclerostin)
R58Q (p.Arg58Gln) in SOST (Sclerostin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
R58Q (p.Arg58Gln) variant details
- p.Arg58Gln
- ESP rs141856582
- ExAC rs141856582
- Missense
- Variant Prioritization Score for Impact Estimate 0.409
- REVEL 0.18
- CADD 21.60
- PolyPhen-2 0.01
- SIFT 0.57
- Most common in the Ashkenazi Jewish population (allele frequency 3.8e-05)
- Structural context available