R19C (p.Arg19Cys) variant of SOST (Sclerostin)
R19C (p.Arg19Cys) in SOST (Sclerostin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
R19C (p.Arg19Cys) variant details
- p.Arg19Cys
- TOPMed rs772369267
- gnomAD rs772369267
- Missense
- Variant Prioritization Score for Impact Estimate 0.168
- REVEL 0.20
- CADD 9.68
- PolyPhen-2 0.00
- SIFT 0.19
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available