P69H (p.Pro69His) variant of SOST (Sclerostin)
P69H (p.Pro69His) in SOST (Sclerostin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
P69H (p.Pro69His) variant details
- p.Pro69His
- TOPMed rs1261726802
- Missense
- Variant Prioritization Score for Impact Estimate 0.407
- REVEL 0.28
- CADD 23.10
- PolyPhen-2 0.43
- SIFT 0.17
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available