P4L (p.Pro4Leu) variant of SOST (Sclerostin)
P4L (p.Pro4Leu) in SOST (Sclerostin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
P4L (p.Pro4Leu) variant details
- p.Pro4Leu
- gnomAD rs1477850027
- Missense
- Variant Prioritization Score for Impact Estimate 0.375
- REVEL 0.19
- CADD 22.40
- PolyPhen-2 0.04
- SIFT 0.10
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available