L5V (p.Leu5Val) variant of SOST (Sclerostin)
L5V (p.Leu5Val) in SOST (Sclerostin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
L5V (p.Leu5Val) variant details
- p.Leu5Val
- gnomAD rs1974161107
- Missense
- Variant Prioritization Score for Impact Estimate 0.343
- REVEL 0.22
- CADD 15.70
- PolyPhen-2 0.03
- SIFT 0.33
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available