H67Y (p.His67Tyr) variant of SOST (Sclerostin)
H67Y (p.His67Tyr) in SOST (Sclerostin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
H67Y (p.His67Tyr) variant details
- p.His67Tyr
- TOPMed rs1974155825
- gnomAD rs1974155825
- Missense
- Variant Prioritization Score for Impact Estimate 0.413
- REVEL 0.19
- CADD 20.60
- PolyPhen-2 0.10
- SIFT 0.51
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available