H15Y (p.His15Tyr) variant of SOST (Sclerostin)
H15Y (p.His15Tyr) in SOST (Sclerostin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
H15Y (p.His15Tyr) variant details
- p.His15Tyr
- ExAC rs755487430
- TOPMed rs755487430
- gnomAD rs755487430
- Missense
- Variant Prioritization Score for Impact Estimate 0.456
- REVEL 0.28
- CADD 16.40
- PolyPhen-2 0.30
- SIFT 0.90
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available