G92E (p.Gly92Glu) variant of SOST (Sclerostin)
G92E (p.Gly92Glu) in SOST (Sclerostin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.84 / 1. The record also includes population frequency data and structural context.
G92E (p.Gly92Glu) variant details
- p.Gly92Glu
- TOPMed rs1974123349
- Missense
- Variant Prioritization Score for Impact Estimate 0.844
- REVEL 0.87
- CADD 29.40
- PolyPhen-2 0.89
- SIFT 0.00
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available