G63R (p.Gly63Arg) variant of SOST (Sclerostin)
G63R (p.Gly63Arg) in SOST (Sclerostin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.76 / 1. The record also includes population frequency data and structural context.
G63R (p.Gly63Arg) variant details
- p.Gly63Arg
- gnomAD rs1356126797
- Missense
- Variant Prioritization Score for Impact Estimate 0.763
- REVEL 0.75
- CADD 24.60
- PolyPhen-2 0.97
- SIFT 0.06
- Most common in the REMAINING population (allele frequency 5e-05)
- Structural context available