E77V (p.Glu77Val) variant of SOST (Sclerostin)
E77V (p.Glu77Val) in SOST (Sclerostin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data, published literature, and structural context.
E77V (p.Glu77Val) variant details
- p.Glu77Val
- gnomAD 17-43755754-T-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.489
- REVEL 0.47
- CADD 25.20
- PolyPhen-2 0.24
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- Literature evidence available