E77K (p.Glu77Lys) variant of SOST (Sclerostin)
E77K (p.Glu77Lys) in SOST (Sclerostin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data and structural context.
E77K (p.Glu77Lys) variant details
- p.Glu77Lys
- ExAC rs768384322
- TOPMed rs768384322
- gnomAD rs768384322
- Missense
- Variant Prioritization Score for Impact Estimate 0.501
- REVEL 0.39
- CADD 24.80
- PolyPhen-2 0.34
- SIFT 0.03
- Most common in the South Asian population (allele frequency 3.6e-05)
- Structural context available