E77A (p.Glu77Ala) variant of SOST (Sclerostin)
E77A (p.Glu77Ala) in SOST (Sclerostin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data, published literature, and structural context.
E77A (p.Glu77Ala) variant details
- p.Glu77Ala
- gnomAD 17-43755754-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.378
- REVEL 0.28
- CADD 24.50
- PolyPhen-2 0.03
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 9.1e-07)
- Structural context available
- Literature evidence available