D74N (p.Asp74Asn) variant of SOST (Sclerostin)
D74N (p.Asp74Asn) in SOST (Sclerostin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
D74N (p.Asp74Asn) variant details
- p.Asp74Asn
- gnomAD rs1182524882
- Missense
- Variant Prioritization Score for Impact Estimate 0.438
- REVEL 0.19
- CADD 27.60
- PolyPhen-2 0.16
- SIFT 0.20
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available