L15P (p.Leu15Pro) variant of SORL1 (Sortilin-related receptor)
L15P (p.Leu15Pro) in SORL1 (Sortilin-related receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data and structural context.
L15P (p.Leu15Pro) variant details
- p.Leu15Pro
- 1000Genomes rs1860812638
- Missense
- Variant Prioritization Score for Impact Estimate 0.583
- REVEL 0.63
- CADD 25.60
- PolyPhen-2 0.98
- SIFT 0.06
- Most common in the 1KG:GWD population (allele frequency 0.0043)
- Structural context available