P46L (p.Pro46Leu) variant of SOCS1 (O15524)
P46L (p.Pro46Leu) in SOCS1 (O15524) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
P46L (p.Pro46Leu) variant details
- p.Pro46Leu
- TOPMed rs1404861826
- gnomAD rs1404861826
- Missense
- Variant Prioritization Score for Impact Estimate 0.221
- REVEL 0.06
- CADD 21.20
- PolyPhen-2 0.00
- SIFT 0.14
- Most common in the Non-Finnish European population (allele frequency 5.9e-05)
- Structural context available