C42Y (p.Cys42Tyr) variant of SOCS1 (O15524)
C42Y (p.Cys42Tyr) in SOCS1 (O15524) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
C42Y (p.Cys42Tyr) variant details
- p.Cys42Tyr
- cosmic curated COSV59662
- gnomAD rs1306590732
- Missense
- Variant Prioritization Score for Impact Estimate 0.221
- REVEL 0.07
- CADD 18.80
- PolyPhen-2 0.01
- SIFT 0.27
- Most common in the South Asian population (allele frequency 2.1e-05)
- Structural context available