C42S (p.Cys42Ser) variant of SOCS1 (O15524)
C42S (p.Cys42Ser) in SOCS1 (O15524) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
C42S (p.Cys42Ser) variant details
- p.Cys42Ser
- gnomAD rs1306590732
- Missense
- Variant Prioritization Score for Impact Estimate 0.203
- REVEL 0.05
- CADD 15.50
- PolyPhen-2 0.00
- SIFT 0.87
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available