M127L (p.Met127Leu) variant of SNCA (Alpha-synuclein)
M127L (p.Met127Leu) in SNCA (Alpha-synuclein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
M127L (p.Met127Leu) variant details
- p.Met127Leu
- rs575502104
- gnomAD 4-89702339-T-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.0901
- CADD 1.33
- Population evidence available
- Structural context available
- Deep Mutational Scanning of alpha-Synuclein based on Toxicity in Yeast Treated w: score -0.0928
- Literature evidence available