A140V (p.Ala140Val) variant of SNCA (Alpha-synuclein)

Name: SNCA A140V (p.Ala140Val) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-06-10
License: https://catvariant.com/terms-of-use

A140V (p.Ala140Val) in SNCA (Alpha-synuclein) is a protein-truncating change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.

A140V (p.Ala140Val) variant details

p.Ala140Val
rs1560475704
gnomAD 4-89702336-ACATGG
Frameshift
Variant Prioritization Score for Impact Estimate 0.0783
CADD 0.68
Population evidence available
Structural context available
Deep Mutational Scanning of alpha-Synuclein based on Toxicity in Yeast Treated w: score -0.0323
Literature evidence available