S32T (p.Ser32Thr) variant of SMAD4 (SMAD family member 4)
S32T (p.Ser32Thr) in SMAD4 (SMAD family member 4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes structural context.
S32T (p.Ser32Thr) variant details
- p.Ser32Thr
- NCI-TCGA TCGA novel
- Ensembl rs2144400871
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.315
- REVEL 0.13
- ESM-1b 1.00
- AlphaMissense 0.14
- MetaLR 0.23
- MetaSVM -0.85
- CADD 24.10
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available