L23F (p.Leu23Phe) variant of SMAD4 (SMAD family member 4)

L23F (p.Leu23Phe) in SMAD4 (SMAD family member 4) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Familial thoracic aortic aneurysm and aortic dissection; Hereditary cancer-predi. The record also includes structural context.

L23F (p.Leu23Phe) variant details