R22G (p.Arg22Gly) variant of SLCO1B1 (Q9Y6L6)
R22G (p.Arg22Gly) in SLCO1B1 (Q9Y6L6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, published literature, and structural context.
R22G (p.Arg22Gly) variant details
- p.Arg22Gly
- gnomAD 12-21141638-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.211
- REVEL 0.23
- MetaLR 0.17
- MetaSVM -0.97
- CADD 9.92
- PolyPhen-2 0.01
- SIFT 0.51
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available
- Literature evidence available