A45T (p.Ala45Thr) variant of SLCO1B1 (Q9Y6L6)
A45T (p.Ala45Thr) in SLCO1B1 (Q9Y6L6) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
A45T (p.Ala45Thr) variant details
- p.Ala45Thr
- rs555367334
- NCI-TCGA Cosmic COSV5700
- NCI-TCGA Cosmic COSV5701
- 1000Genomes rs555367334
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.327
- REVEL 0.17
- CADD 21.50
- PolyPhen-2 0.06
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available