R98W (p.Arg98Trp) variant of SLC8A1 (Sodium/calcium exchanger 1)
R98W (p.Arg98Trp) in SLC8A1 (Sodium/calcium exchanger 1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data and structural context.
R98W (p.Arg98Trp) variant details
- p.Arg98Trp
- rs1559653918
- NCI-TCGA Cosmic COSV6047
- cosmic curated COSV60477
- Ensembl rs1559653918
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.572
- REVEL 0.62
- CADD 26.10
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available