Y134F (p.Tyr134Phe) variant of SLC6A4 (P31645)
Y134F (p.Tyr134Phe) in SLC6A4 (P31645) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.63 / 1. The record also includes population frequency data and structural context.
Y134F (p.Tyr134Phe) variant details
- p.Tyr134Phe
- 1000Genomes rs575214286
- ExAC rs575214286
- gnomAD rs575214286
- Missense
- Variant Prioritization Score for Impact Estimate 0.629
- REVEL 0.64
- ESM-1b 1.00
- AlphaMissense 0.09
- MetaLR 0.55
- MetaSVM -0.03
- CADD 24.80
- Most common in the HGDP:SAN population (allele frequency 0.25)
- Structural context available