M135T (p.Met135Thr) variant of SLC6A4 (P31645)
M135T (p.Met135Thr) in SLC6A4 (P31645) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.77 / 1. The record also includes population frequency data and structural context.
M135T (p.Met135Thr) variant details
- p.Met135Thr
- ExAC rs764034794
- TOPMed rs764034794
- gnomAD rs764034794
- Missense
- Variant Prioritization Score for Impact Estimate 0.773
- REVEL 0.87
- ESM-1b 1.00
- AlphaMissense 0.80
- MetaLR 0.63
- MetaSVM 0.36
- CADD 26.20
- Most common in the 1KG:MSL population (allele frequency 0.31)
- Structural context available