M135L (p.Met135Leu) variant of SLC6A4 (P31645)
M135L (p.Met135Leu) in SLC6A4 (P31645) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
M135L (p.Met135Leu) variant details
- p.Met135Leu
- gnomAD rs1274463771
- Missense
- Variant Prioritization Score for Impact Estimate 0.356
- REVEL 0.21
- ESM-1b 1.00
- AlphaMissense 0.17
- MetaLR 0.18
- MetaSVM -0.94
- CADD 21.20
- Most common in the Latino/Admixed American population (allele frequency 0.00011)
- Structural context available