L74F (p.Leu74Phe) variant of SLC6A4 (P31645)
L74F (p.Leu74Phe) in SLC6A4 (P31645) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
L74F (p.Leu74Phe) variant details
- p.Leu74Phe
- Ensembl rs2143015505
- Missense
- Variant Prioritization Score for Impact Estimate 0.224
- REVEL 0.11
- ESM-1b 0.00
- AlphaMissense 0.08
- MetaLR 0.26
- MetaSVM -0.87
- CADD 7.92
- Most common in the African/African-American population (allele frequency 9.7e-05)
- Structural context available