L6S (p.Leu6Ser) variant of SLC6A4 (P31645)
L6S (p.Leu6Ser) in SLC6A4 (P31645) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
L6S (p.Leu6Ser) variant details
- p.Leu6Ser
- gnomAD rs1406941594
- Missense
- Variant Prioritization Score for Impact Estimate 0.412
- REVEL 0.43
- ESM-1b 0.00
- AlphaMissense 0.12
- MetaLR 0.35
- MetaSVM -0.85
- CADD 22.70
- Most common in the Non-Finnish European population (allele frequency 2.5e-05)
- Structural context available