K84R (p.Lys84Arg) variant of SLC6A4 (P31645)
K84R (p.Lys84Arg) in SLC6A4 (P31645) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
K84R (p.Lys84Arg) variant details
- p.Lys84Arg
- rs774467106
- NCI-TCGA Cosmic COSV5556
- cosmic curated COSV55565
- ExAC rs774467106
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.438
- REVEL 0.46
- ESM-1b 0.00
- AlphaMissense 0.08
- MetaLR 0.44
- MetaSVM -0.15
- CADD 24.20
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the 1KG:MSL population (allele frequency 0.19)
- Structural context available