I108V (p.Ile108Val) variant of SLC6A4 (P31645)
I108V (p.Ile108Val) in SLC6A4 (P31645) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
I108V (p.Ile108Val) variant details
- p.Ile108Val
- 1000Genomes rs56316081
- ExAC rs56316081
- TOPMed rs56316081
- gnomAD rs56316081
- Missense
- Variant Prioritization Score for Impact Estimate 0.246
- REVEL 0.18
- ESM-1b 0.13
- AlphaMissense 0.09
- MetaLR 0.26
- MetaSVM -0.71
- CADD 22.10
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available