F127C (p.Phe127Cys) variant of SLC6A4 (P31645)
F127C (p.Phe127Cys) in SLC6A4 (P31645) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.69 / 1. The record also includes population frequency data and structural context.
F127C (p.Phe127Cys) variant details
- p.Phe127Cys
- ExAC rs780022333
- TOPMed rs780022333
- gnomAD rs780022333
- Missense
- Variant Prioritization Score for Impact Estimate 0.685
- REVEL 0.71
- ESM-1b 1.00
- AlphaMissense 0.18
- MetaLR 0.59
- MetaSVM 0.15
- CADD 29.80
- Most common in the HGDP:PAPUANSEPIK population (allele frequency 1)
- Structural context available