C109W (p.Cys109Trp) variant of SLC6A4 (P31645)
C109W (p.Cys109Trp) in SLC6A4 (P31645) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.67 / 1. The record also includes population frequency data and structural context.
C109W (p.Cys109Trp) variant details
- p.Cys109Trp
- TOPMed rs1906762930
- gnomAD rs1906762930
- Missense
- Variant Prioritization Score for Impact Estimate 0.666
- REVEL 0.82
- ESM-1b 1.00
- AlphaMissense 1.00
- MetaLR 0.67
- MetaSVM 0.41
- CADD 26.20
- Most common in the 1KG:MSL population (allele frequency 0.31)
- Structural context available