V4M (p.Val4Met) variant of SLC22A1 (O15245)
V4M (p.Val4Met) in SLC22A1 (O15245) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
V4M (p.Val4Met) variant details
- p.Val4Met
- rs756880870
- ExAC rs756880870
- gnomAD rs756880870
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.163
- REVEL 0.17
- CADD 3.36
- PolyPhen-2 0.07
- SIFT 0.08
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 9e-05)
- Structural context available