T10M (p.Thr10Met) variant of SIX1 (Homeobox protein SIX1)
T10M (p.Thr10Met) in SIX1 (Homeobox protein SIX1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.79 / 1. The record also includes population frequency data, experimental measurements, and structural context.
T10M (p.Thr10Met) variant details
- p.Thr10Met
- TOPMed rs1417956063
- gnomAD rs1417956063
- Missense
- Variant Prioritization Score for Impact Estimate 0.788
- CADD 27.50
- PolyPhen-2 0.71
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 0.00041)
- Structural context available
- SIX1 Homeobox domain domainome 1.0: score -0.0803