G25R (p.Gly25Arg) variant of SIX1 (Homeobox protein SIX1)
G25R (p.Gly25Arg) in SIX1 (Homeobox protein SIX1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.82 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G25R (p.Gly25Arg) variant details
- p.Gly25Arg
- cosmic curated COSV10630
- gnomAD rs1009804624
- Missense
- Variant Prioritization Score for Impact Estimate 0.817
- CADD 29.80
- PolyPhen-2 0.95
- SIFT 0.01
- Most common in the 1KG:MXL population (allele frequency 0.0081)
- Structural context available
- SIX1 Homeobox domain domainome 1.0: score 0.0916