S141T (p.Ser141Thr) variant of SIRT7 (Q9NRC8)
S141T (p.Ser141Thr) in SIRT7 (Q9NRC8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
S141T (p.Ser141Thr) variant details
- p.Ser141Thr
- TOPMed rs1293618680
- gnomAD rs1293618680
- Missense
- Variant Prioritization Score for Impact Estimate 0.361
- REVEL 0.17
- ESM-1b 1.00
- AlphaMissense 0.18
- MetaLR 0.04
- MetaSVM -1.08
- CADD 19.85
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available