R66W (p.Arg66Trp) variant of SIRT7 (Q9NRC8)
R66W (p.Arg66Trp) in SIRT7 (Q9NRC8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
R66W (p.Arg66Trp) variant details
- p.Arg66Trp
- TOPMed rs1410228022
- gnomAD rs1410228022
- Missense
- Variant Prioritization Score for Impact Estimate 0.286
- REVEL 0.14
- ESM-1b 1.00
- AlphaMissense 0.14
- MetaLR 0.04
- MetaSVM -1.11
- CADD 25.20
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available