R66P (p.Arg66Pro) variant of SIRT7 (Q9NRC8)
R66P (p.Arg66Pro) in SIRT7 (Q9NRC8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
R66P (p.Arg66Pro) variant details
- p.Arg66Pro
- 1000Genomes rs577056649
- TOPMed rs577056649
- Missense
- Variant Prioritization Score for Impact Estimate 0.323
- REVEL 0.12
- ESM-1b 1.00
- AlphaMissense 0.49
- MetaLR 0.02
- MetaSVM -1.05
- CADD 22.60
- Most common in the 1KG:LWK population (allele frequency 0.0058)
- Structural context available