R66L (p.Arg66Leu) variant of SIRT7 (Q9NRC8)
R66L (p.Arg66Leu) in SIRT7 (Q9NRC8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
R66L (p.Arg66Leu) variant details
- p.Arg66Leu
- 1000Genomes rs577056649
- TOPMed rs577056649
- Missense
- Variant Prioritization Score for Impact Estimate 0.242
- REVEL 0.12
- ESM-1b 0.00
- AlphaMissense 0.10
- MetaLR 0.02
- MetaSVM -1.03
- CADD 21.20
- Population evidence available
- Structural context available