R21W (p.Arg21Trp) variant of SIRT7 (Q9NRC8)
R21W (p.Arg21Trp) in SIRT7 (Q9NRC8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
R21W (p.Arg21Trp) variant details
- p.Arg21Trp
- ExAC rs779610329
- TOPMed rs779610329
- gnomAD rs779610329
- Missense
- Variant Prioritization Score for Impact Estimate 0.358
- REVEL 0.15
- ESM-1b 1.00
- AlphaMissense 0.19
- MetaLR 0.04
- MetaSVM -1.11
- CADD 24.20
- Most common in the Ashkenazi Jewish population (allele frequency 4.1e-05)
- Structural context available