R21G (p.Arg21Gly) variant of SIRT7 (Q9NRC8)
R21G (p.Arg21Gly) in SIRT7 (Q9NRC8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
R21G (p.Arg21Gly) variant details
- p.Arg21Gly
- ExAC rs779610329
- TOPMed rs779610329
- gnomAD rs779610329
- Missense
- Variant Prioritization Score for Impact Estimate 0.274
- REVEL 0.07
- ESM-1b 0.40
- AlphaMissense 0.12
- MetaLR 0.04
- MetaSVM -1.08
- CADD 23.20
- Most common in the Finnish in Finland (FIN) population (allele frequency 2.7e-05)
- Structural context available