P122S (p.Pro122Ser) variant of SIRT7 (Q9NRC8)
P122S (p.Pro122Ser) in SIRT7 (Q9NRC8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
P122S (p.Pro122Ser) variant details
- p.Pro122Ser
- 1000Genomes rs200803537
- gnomAD rs200803537
- Missense
- Variant Prioritization Score for Impact Estimate 0.376
- REVEL 0.21
- ESM-1b 0.16
- AlphaMissense 0.75
- MetaLR 0.05
- MetaSVM -1.12
- CADD 23.90
- Most common in the 1KG:CHS population (allele frequency 0.0049)
- Structural context available