G4R (p.Gly4Arg) variant of SIRT7 (Q9NRC8)
G4R (p.Gly4Arg) in SIRT7 (Q9NRC8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
G4R (p.Gly4Arg) variant details
- p.Gly4Arg
- gnomAD rs1396320144
- Missense
- Variant Prioritization Score for Impact Estimate 0.269
- REVEL 0.07
- ESM-1b 0.00
- AlphaMissense 0.40
- MetaLR 0.07
- MetaSVM -1.08
- CADD 23.40
- Most common in the Middle Eastern population (allele frequency 0.00025)
- Structural context available