G4A (p.Gly4Ala) variant of SIRT7 (Q9NRC8)
G4A (p.Gly4Ala) in SIRT7 (Q9NRC8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
G4A (p.Gly4Ala) variant details
- p.Gly4Ala
- ExAC rs746408225
- gnomAD rs746408225
- Missense
- Variant Prioritization Score for Impact Estimate 0.263
- REVEL 0.07
- ESM-1b 0.00
- AlphaMissense 0.09
- MetaLR 0.05
- MetaSVM -1.09
- CADD 21.70
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available