G132W (p.Gly132Trp) variant of SIRT7 (Q9NRC8)
G132W (p.Gly132Trp) in SIRT7 (Q9NRC8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.62 / 1. The record also includes population frequency data and structural context.
G132W (p.Gly132Trp) variant details
- p.Gly132Trp
- ExAC rs747980774
- gnomAD rs747980774
- Missense
- Variant Prioritization Score for Impact Estimate 0.616
- REVEL 0.49
- ESM-1b 1.00
- AlphaMissense 0.95
- MetaLR 0.22
- MetaSVM -0.29
- CADD 33.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available